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KMID : 0360919720150020065
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Journal of the Korean Medical Association
1972 Volume.15 No. 2 p.65 ~ p.67
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STUDIES ON EFFECTIVENESS OF JAPANESE B ENCEPHALITIS VACCINATION
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Lee, Martin Hodges
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Abstract
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Two hundred and nine American ´Peace Corps Volun-
teers were divided into two Groups. All of them were
known to have been free from current or previous Ja-
panese B encephalitis infection. None of ahem had a
history of Japanese B encephalitis vaccination.
Group I included 106 members who had come to
before November 1, 1970. They had already
received two vaccinations for primary immunization in
July, 1970. Therefore they were given only one subcu-
taneous booster injection in July 1971.
209 a n i 1 0 l o }~} 1(214 -25A11)011.711 21- Group 2 included 103 members who had come to
01 11 q n 11 ll &~_ 7,j a a} L ´A Il 0~ 71-g- Korea after November 1, 1970. They were given two
0 7}- l ~} H-I al 4 ~1 Al ~ 4o a 4. primary immunizations three weeks apart in July 1971.
1, ~ o ,?01 T } ~,j o X011 ~j }oj Hof In both groups 1 and 2 blood samples were drawn
47go o 71 O _V_ ~a L}, two times from each member. , These times were: just
2. 01 L -L R 14 -~I_ ´; 110:7 , H-1 aol 11a 6l 97}1- before and two weeks after vaccination was completed
711 ~1 }mil **o tl-q r_ Cq 71 -l4. in" July of 1971. All blood samples were then transferred
77
to the Korean National Institute of Health and tested
<01 `´-~a ~1L -7,-1 71
1 a 7.1- ~ c yas r for hemog$lutination-inhibition antibody titers,
Leo ,;~ ´ 7-1 l 1 ~l t11 z u1 l 1 Liz
a} z11 .--z 401 a}~l s1 X11L1} ~ L y1 }two} ~~ ~j H-1 antibody titers from samples drawn before vaccina-
U~~} nr ~~hj ~~ n X1 1 7,}A} 2e] 0 01 r+> tion in July 1971 were less than 1 : 10 for all members
o -both groups.
L There were no differences in pre and post vaccination
1) r~, 4EM9 - 93K, *Am: R*16yA W W& H-I antibody titers between the two groups. For both
H-y#-n,r.- )j f aVso11 It l yo}~ , 14: 563, groups there was a 47%- positive immunization rate as
1971. Judged by H-I antibody titer rise.
2) Clarke, D. H. and Casals,, J.: Technique for Hemagglu
tination and H=I with Arthropode ´Borne Viruses, Japanese B encephalitis vaccines are produced in Japan
Ana. J. Trop. Med. Hyg., 7: 561, 1968, and Korea. These vaccines produced are formalin-killed´
3) Horsfall, F. L. Jr, and Tomm, I.: Viral and Rickettsial
Infections of Man, 4th ed. J. P. Lippincott Co. Phila- mouse brain vaccines. These killed vaccines are not very
delphia, 1965, p 63j. antigenic and might not be very effective in preventing
4) Matsuda, S.: An Epidemiologic Studies of Japanese B Japanese B encephalitis infection. Live-attenuated vaccine
Encephalitis with Special Refrane´e to the Effectiveness
´ of Vaccination,´ Bull, Inst. Pub. Health, 11: 173, should be prepared as in the Base of polimyelitis and
1962, measles for- complete eradication of Japanese B encephalitis
x a~ ~) 7 (2) q)l ^ "
r
367. in the future.
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